ANT431 sodium ( ANT 431;ANT-431 )

Catalog No. M17103 CAS No.

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ANT431 sodium
Note

Research use only, not for human use.
Brief Description

ANT431 sodium is a novel, highly water-soluble metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2.
Description

ANT431 sodium is a novel, highly water-soluble metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2, shows a comparatively weak inhibitor of VIM-1 and IMP-1 (Ki of 14.6 and 4.15 uM, respectively); potentiate the activity of meropenem (MEM) against a broad range of MBL-producing carbapenem-resistant Enterobacteriaceae (CRE), restore its efficacy against an Escherichia coli NDM-1 strain in a murine thigh infection model.
Synonyms

ANT 431;ANT-431
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

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Indication

——

CAS Number

--
Formula Weight

308.28
Molecular Formula

C9H7N3NaO4S2
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

5-(pyridine-3-sulfonamido)thiazole-4-carboxylic acid, sodium salt

1. Everett M, et al. Antimicrob Agents Chemother. 2018 Mar 12. pii: AAC.00074-18.

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